Singles matchups, seeds and recorded results by round. Draw information appears as it is published.
Carlos Alcaraz won the Monte Carlo 2025 men's singles title from a draw of 56 players, beating Lorenzo Musetti 3-6 6-1 6-0 in the final.
15 players are seeded in the Monte Carlo 2025 men's singles draw, led by No. 1 seed Alexander Zverev; the No. 2 seed Carlos Alcaraz won the title.
| Seed | Player | Rank | Fate |
|---|---|---|---|
| 1 | Alexander Zverev | #4 | Round of 32 |
| 2 | Carlos Alcaraz | #1 | Champion |
| 3 | Novak Djokovic | #3 | Round of 32 |
| 4 | Casper Ruud | #13 | Round of 16 |
| 5 | Jack Draper | #14 | Round of 16 |
| 6 | Stefanos Tsitsipas | #43 | Quarterfinals |
| 7 | Andrey Rublev | #17 | Round of 16 |
| 8 | Alex De Minaur | #6 | Semifinals |
| 9 | Daniil Medvedev | #11 | Round of 16 |
| 11 | Ben Shelton | #14 | Round of 64 |
| 12 | Arthur Fils | #15 | Quarterfinals |
| 13 | Lorenzo Musetti | #16 | Runner-up |
| 14 | Frances Tiafoe | #17 | Round of 32 |
| 15 | Grigor Dimitrov | #18 | Quarterfinals |
| 16 | Felix Auger-Aliassime | #19 | Round of 64 |
All 24 matches in the Round of 64 are complete and 8 players received a bye.
All 16 matches in the Round of 32 are complete.
All 8 matches in the Round of 16 are complete.
All 4 matches in the Quarterfinals are complete.
All 2 matches in the Semifinals are complete.
Carlos Alcaraz beat Lorenzo Musetti 3-6 6-1 6-0 in the final.